San Francisco (4-1) at Tampa Bay (4-1)

BetMGM NFL Odds: Buccaneers by 3.

Against the spread: 49ers 4-1; Buccaneers 3-2.

Series record: 49ers lead 21-7.

Last meeting: 49ers beat Buccaneers 23-20 on Nov. 10, 2024, in Tampa Bay.

Last week: 49ers beat Rams 26-23; Buccaneers beat Seahawks 38-35.

49ers offense: overall (5), rush (28t), pass (1), scoring (22)

49ers defense: overall (15), rush (15), pass (14), scoring (6t)

Buccaneers offense: overall (11), rush (22), pass (6), scoring (7)

Buccaneers defense: overall (11), rush (8t), pass (20), scoring (22)

Turnover differential: 49ers minus-3; Buccaneers plus-2.

WR Kendrick Bourne. The Niners signed Bourne after the opener and he has been making a big impact in his second stint in San Francisco. Bourne had 10 catches last week for a career-high 142 yards. It was his second career 100-yard game with the other coming in 2022 with New England.

WR Emeka Egbuka. With Mike Evans sidelined by injury, the rookie has stepped into a dynamic playmaking role. Egbuka has 25 receptions for 445 yards and five TDs.

49ers RT Colton McKivitz vs. Buccaneers OLB Haason Reddick. The Buccaneers didn’t sack Sam Darnold last week, but a blitz pressured him into an errant throw that resulted in a game-turning interception. Reddick has only one sack in five games, but he has 19 pressures.

49ers: QB Brock Purdy could miss his fourth game with a toe injury with Mac Jones slated to start if Purdy can’t go. ... WR Ricky Pearsall (knee) is expected to miss his second straight game. ... WR Jauan Jennings (ankle, ribs) could also miss a second straight game. ... DT Alfred Collins’ status is also in doubt with a knee injury. ... S Malik Mustapaha (knee) and DT Kevin Givens (pectoral) had their practice windows opened this week and could play Sunday.

Buccaneers: TE Ko Kieft (leg) was lost for the season. RT Luke Goedeke (foot) is out and G Cody Mauch (knee) is also done for the season. ... Evans (hamstring) and RB Bucky Irving (foot, shoulder) are likely out. ... WR Chris Godwin (fibula), CB Benjamin Morrison (hamstring) and CB Zyon McCollum (thumb) didn’t practice Wednesday.

The 49ers have dominated the series recently, winning the last four meetings. Niners coach Kyle Shanahan is 4-1 against Tampa Bay. Bucs coach Todd Bowles is 1-3 vs. San Francisco.

McCaffrey has 282 yards rushing and 387 receiving. He’s on pace to catch 133 passes this season.

AP NFL: https://apnews.com/hub/nfl