Minnesota (2-2) vs. Cleveland (1-3) in London.

Sunday, 9:30 a.m. EDT, NFL Network.

BetMGM NFL Odds: Vikings by 3½.

Against the spread: Vikings 2-2; Browns 2-2.

Series record: Vikings lead 12-5.

Last meeting: Browns beat Vikings 14-7 in Minneapolis on Oct. 3, 2021.

Last week: Vikings lost to Steelers 24-21 in Dublin, Ireland; Browns lost at Lions 34-10.

Vikings offense: overall (23), rush (20), pass (24), scoring (10).

Vikings defense: overall (7), rush (24), pass (3), scoring (9).

Browns offense: overall (27), rush (30), pass (20), scoring (31).

Browns defense: overall (1), rush (1), pass (4), scoring (24).

Turnover differential: Vikings even; Browns minus-6.

RT Justin Skule. Injuries have ravaged what the Vikings were counting on to be an upgraded offensive line this season, with RT Brian O’Neill (knee) the latest to be sidelined and three starters unavailable this week. Skule struggled in pass protection while subbing for LT Christian Darrisaw in the first two games, and the Browns led by four-time All-Pro Myles Garrett have one of the best defensive fronts in the league.

Rookie QB Dillon Gabriel will make his first NFL start, replacing an ineffective Joe Flacco. The third-round pick showed quick decision-making and some mobility in two preseason games and has seen mop-up duty in two regular-season games. Gabriel becomes the 41st starting quarterback since the Browns returned in 1999, the 12th since Kevin Stefanski became coach in 2020 and the fifth in 10 games going back to last season.

Vikings DL Jonathan Allen vs. Browns LG Joel Bitonio. Allen has forced 183 quarterback pressures since 2021, the 10th most by a interior pass rusher according to the NFL’s Next Gen Stats and has five tackles for no gain or a loss as a run defender. Bitonio has allowed a pressure on just 4% of his pass blocks, fifth lowest in the league. He has not allowed a sack this season or more than five pressures in any game since last year’s opener. Allen, who has yet to have a sack in his first season with the Vikings, is fourth on the team with 18 tackles.

Vikings: In addition to O’Neill, C Ryan Kelly (concussion) is out indefinitely and LG Donovan Jackson (wrist) will miss at least one more game along with QB J.J. McCarthy (ankle). OLB Andrew Van Ginkel (neck) will also miss his second straight game and third in four weeks. Kelly’s backup, Michael Jurgens (hamstring), was held out of practice on Wednesday, but the Vikings are hoping he’ll play. RB Aaron Jones (hamstring) and LB Blake Cashman (hamstring) remain on injured reserve.

Browns: DE Myles Garrett (ankle) did not practice on Wednesday and is considered day to day by coach Kevin Stefanski, putting his status for the game in question. Backup DT Mike Hall (knee) has already been ruled out and did not make the trip to London. RT Jack Conklin (elbow), who has missed the past three games, was limited in practice this week.

This is the second time the two teams have faced each other in London, with the Vikings beating the Browns 33-16 at Twickenham Stadium in 2017. This game will be played at Tottenham Hotspur Stadium. ... Factoring in the new club the Browns were awarded in 1999 after the original franchise moved to Baltimore in 1996, the league’s scheduling formula reset in 2002 for the divisional realignment to accommodate a 32nd team and these two matchups in London, the Vikings will only play one game in Cleveland (2009) in a staggering 43-year stretch until they’re on track to visit there in 2033. ... Adrian Peterson rushed for 180 yards and three touchdowns in Brett Favre’s first game with the Vikings in a 34-20 victory on Sept. 13, 2009, the most recent time the two teams played in Cleveland. ... The away team has won the past four meetings in the series.

Vikings RB Zavier Scott would be worth a pickup in deeper leagues as a bye-week or injury fill-in. With Jones and backup RB Ty Chandler out, the undrafted rookie has become a viable complement to featured runner Jordan Mason. Scott had 10 carries and nine passing targets last week against the Steelers, racking up seven receptions for 63 yards and a touchdown.

AP NFL: https://apnews.com/hub/nfl