Last week was the toughest of the season for Associated Press Top 25 teams as a group, with five losing to unranked opponents a week after three others went down the same way.

Big picture, the upper echelon of the sport is on track to have one of its better seasons against the unranked.

The Top 25 is 95-17 against unranked opponents for an .848 winning percentage that, if it holds, would be tied for fifth-best since at least 2000, according to Sportradar. Last year, the Top 25 was 191-41 (.823).

Teams in the top 10 when they played unranked opponents are 32-5 through Week 7, with Penn State’s loss to UCLA the one we remember best. The .865 winning percentage is middle-of-the-pack since 2000 but well ahead of the top 10’s record of 78-15 (.839) for the 2024 season.

Over the last quarter century, 2006 ranks as the best for the Top 25 (206-30, .873) and 2010 the best for the top 10 (79-4, .952).

Enough geeking out. Here are picks for this week’s games involving AP Top 25 teams and lines from BetMGM Sportsbook:

No. 1 Ohio State (minus 25 1/2) at Wisconsin

The Badgers haven’t scored more than 14 points against a power-conference opponent and are coming off a 37-0 home loss to Iowa. Ohio State is allowing just 6.8 points per game to lead nation.

Think you know who belongs in the Top 25? Now it’s your turn to vote with the AP Top 25 fan poll.

Louisville (plus 13 1/2) at No. 2 Miami

The Cardinals’ offensive line could have a problem coping with Miami’s ferocious front seven, though the last two meetings were decided by a touchdown.

Michigan State at No. 3 Indiana (minus 27 1/2)

The Spartans have lost three straight and Jonathan Smith’s job security is getting shaky. Don’t expect the Hoosiers to take their foot off the gas.

No. 4 Texas A&M (minus 7 1/2) at Arkansas

Experienced backup Rueben Owens II is set to take over as Aggies’ primary ball-carrier for the injured Le’Veon Moss. Arkansas has scored at least 31 points in all but one of its six games and is still just 2-4.

No. 5 Mississippi (plus 7) at No. 9 Georgia

Mississippi QB Trinidad Chambliss’s first road start comes at Sanford Stadium in Athens, where the Rebels haven’t won since 1996.

No. 11 Tennessee at No. 6 Alabama (minus 8 1/2)

Crimson Tide have beaten three straight ranked opponents, are 10-0 at home under second-year coach Kalen DeBoer and have won 10 straight against the Volunteers in Tuscaloosa.

No. 7 Texas Tech (minus 9 1/2) at Arizona State

Both teams have uncertain quarterback situations. Tech has the better backup. The Red Raiders also have one of the most disruptive defenses in the country.

No. 8 Oregon at Rutgers (plus 17)

The Ducks, who are making their second cross-country trip in three weeks, take out some frustration after its loss to Indiana. The Scarlet Knights are desperate to avoid a fourth straight loss.

No. 10 LSU (plus 2 1/2) at No. 17 Vanderbilt

Commodores are favored against LSU for the first time since 1948 and for the first time against a ranked opponent since at least 1978, according to CBS Sports Research.

No. 12 Georgia Tech at Duke (minus 1 1/2)

Since coughing up the ball five times against Illinois five weeks ago, the Blue Devils have committed one turnover and recorded 12 takeaways.

No. 20 Southern California (plus 9 1/2) at No. 13 Notre Dame

The Fighting Irish have allowed a total of 27 points over last three games but Jayden Maiava and the Trojans’ offense are hot.

No. 14 Oklahoma at South Carolina (plus 5 1/2)

John Mateer had a rough outing against Texas in his first game after thumb surgery. He declared himself 100% this week.

No. 23 Utah at No. 15 BYU (plus 3 1/2)

This matchup of the top two rushing offenses in the Big 12 will come down to which team stops the run better. The Cougars have been a bit better at that.

No. 16 Missouri (minus 1 1/2) at Auburn

Missouri totaled nine sacks in their first two SEC games. Only one QB has been sacked more than Auburn’s Jackson Arnold (21).

Washington State at No. 18 Virginia (minus 17 1/2)

Virginia should be fresh after an open date. Fatigue could be a factor for Cougars, who are playing their third straight road game and second in a row east of the Mississippi River.

Florida Atlantic at No. 19 South Florida (minus 21 1/2)

FAU’s Air Raid offense generates lots of yards, but Caden Veltkampit has a problem with interceptions (9). Only five teams have picked off more passes than the Bulls (9).

No. 21 Texas (minus 12 1/2) at Kentucky

Arch Manning, coming off back-to-back games against top-40 defenses, should have an opportunity to break out.

No. 22 Memphis at UAB (plus 21 1/2)

The Blazers are playing their first game since the firing of Trent Dilfer. Brendon Lewis-led Tigers should be able to move ball at will against American Conference’s worst defense.

No. 24 Cincinnati (minus 21 1/2) at Oklahoma State

Streaking Bearcats average 6.23 yards per carry, fifth-best nationally, and Brendan Sorsby is 10th in passer rating. The Cowboys’ defense is second worst in the FBS.

No. 25 Nebraska at Minnesota (plus 7 1/2)

Nebraska fans are talking more this week about whether Matt Rhule will bolt for Penn State than they are about the Gophers. Huskers have lost five straight to Minnesota.

Last week: Straight-up — 13-5; Against spread — 8-9-1.

Season: Straight-up — 92-20; Against spread — 54-57-1.